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STEP 1 [5] (Wilding et al., NEJM , 2021) Supplementary Appendix

berberine is contraindicated in pregnancy and breastfeeding

Patients who combine pharmacotherapy with reduced caloric intake and regular exercise typically achieve faster and more substantial weight loss compared to those relying on medication alone

This means that it mimics the action of the hormone ghrelin, causing the pituitary gland to release the growth hormone

Hypothyroidism occurs when the thyroid gland doesnt produce enough thyroid hormone